The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the following technical areas: development of a nano-scale heterogeneous material synthesis on lattice mismatch substrates to realize defect-free multi-layer heterogenous junctions with atomically sharp surface/interface and atomically abrupt compositional transition. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.