The funding opportunity CDC-RFA-JG-25-0095 aims to implement and sustain a comprehensive HIV response and provide technical assistance to strengthen the capacity of regional authorities in Tanzania under the President’s Emergency Plan for AIDS Relief (PEPFAR). The program prioritizes improving the quality of life for people living with HIV, achieving the UNAIDS 95-95-95 targets, and addressing health disparities through enhanced service delivery models, robust health systems, and transformative partnerships.

The NOFO allocates $50 million for the first year, with funding distributed among one to four awardees. Applicants must develop proposals for up to four of the twelve CDC-supported regions in Tanzania, such as Dar es Salaam, Zanzibar, and Mwanza. The award includes five annual budget periods, contingent on funding availability and satisfactory performance. The program prohibits research activities, requires all funds to be justified in U.S. dollars, and encourages alignment with Tanzania's national strategic HIV frameworks.

Eligibility is broad, including U.S. and non-U.S. entities, government bodies, nonprofits, and private organizations, provided activities occur in Tanzania. Proposals must demonstrate capacity to deliver targeted HIV/TB interventions and build the capacity of local health systems. Applications must be submitted via Grants.gov by March 11, 2025, at 11:59 PM ET.

Applicants should address critical objectives such as scaling up innovative prevention and treatment strategies, providing technical assistance, and promoting health equity through culturally sensitive and person-centered services. They are expected to establish systems for data collection and analysis to ensure continuous quality improvement and informed decision-making. Required application materials include a project narrative (20-page limit), budget narrative, work plan, resumes, and an organizational capacity statement.

Evaluation criteria focus on the proposed approach (40 points), organizational capacity (35 points), and data monitoring and evaluation (25 points). A preference of 15 additional points is given to local partners meeting specific PEPFAR definitions. Awards will be announced by August 2025, and funded projects are expected to commence by September 30, 2025.

The CDC will remain substantially involved post-award, offering technical assistance, overseeing progress, and ensuring alignment with national HIV management plans. Recipients must comply with various federal and program-specific requirements, including extensive reporting on outcomes and financial management.