The purpose of this NOFO is to seek applications for a Coordinating Center (CC) for the Multi-Sectoral Preventive Interventions (MSPI) Research Network. Members of the Multi-Sectoral Preventive Interventions (MSPI) Research Network, including the CC and separately funded research projects, will work collaboratively with the NIH to test prospective multi-sectoral preventive interventions that address social determinants of health in populations that experience health disparities. The MSPI Research Network will include the CC funded under this Cooperative Agreement and up to 10 Research Projects funded under the companion UG3/UH3 Phased Cooperative Agreement NOFO, Multi-sectoral preventive interventions that address social determinants of health in populations that experience health disparities. The CC will provide overarching support and guidance to the network in three domains: (1) administration, coordination, and communication; (2) methodology, data, and analytic support and consultation; and (3) community and other collaborator engagement and dissemination support. It is important that applicants for the CC also read the companion NOFO to understand the full mission and structure of the research network.