This Funding Opportunity Announcement (FOA) describes a newly proposed initiative of the Air Force Research Laboratory (AFRL) concerning standing up a University Center of Excellence (CoE) for Data Assimilation (DA) Driven by Mathematical Features Representing Physics with educational institutions in the United States. The University CoE is defined as a joint effort among multiple technical directorates (TDs) of the Air Force Research Laboratory to include: the Air Force Office of Scientific Research (AFOSR), Aerospace Systems Directorate (RQ), Space Vehicles Directorate (RV), and Munitions Directorate (RW), referred to collectively as we, our, or us, in this FOA, and an outstanding university or team of universities that will perform high priority unclassified and collaborative basic / applied (6.1/ 6.2) research which addresses the United States Air Force (USAF) and United States Space Force (USSF) research needs in the DA area with relevance to high-speed flows and combustion.