The National Institutes of Health (NIH) Common Fund, in collaboration with various NIH Institutes, Centers, and Offices, has announced its intent to publish a Notice of Funding Opportunity (NOFO) for the "Advancing Non-Invasive Optical Approaches in Biological Systems" initiative. This program seeks to support the development of next-generation, non-invasive or minimally invasive optical imaging technologies capable of overcoming the challenges of light scattering in biological systems. These technologies aim to achieve high spatial and temporal resolution imaging at significantly greater depths within biological tissues than currently possible. The NOFO will use the UG3/UH3 phased innovation award cooperative agreement mechanism, and clinical trials are not allowed.

The purpose of this initiative is to promote innovative research to enhance the capabilities of optical imaging techniques for biological systems, enabling breakthroughs in understanding biological processes at deeper tissue levels. This will involve a bi-phasic research approach, with the initial UG3 phase focused on establishing feasibility, preparation, and foundational milestones. Projects meeting these milestones may transition to the UH3 phase, where they will be prioritized for further development and application. The program aims to push the boundaries of imaging science, with potential applications in biomedical research and healthcare.

Eligible applicants include a wide range of entities, such as public and private institutions of higher education, state and local governments, Native American tribal governments and organizations, independent school districts, nonprofits with 501(c)(3) status, small businesses, for-profit organizations other than small businesses, and public or Indian housing authorities. This broad eligibility ensures diverse participation in advancing optical imaging technologies.

The NOFO is anticipated to be published on December 7, 2024, with applications due by March 7, 2025. Awards are expected to be announced by December 1, 2025, with projects starting on the same date. Potential applicants should prepare early by forming collaborations and designing projects that align with the program’s goals.

Evaluation criteria will include the feasibility of the proposed technology, its potential for achieving high-resolution imaging at greater depths, and the applicant’s ability to meet the program’s milestones. Strong applications will demonstrate innovative approaches to addressing the limitations of current optical imaging technologies and propose practical steps toward achieving these advancements. Full details on application format, submission guidelines, and review criteria will be outlined in the NOFO.

The estimated total program funding is $4,900,000, with an award ceiling of $1,600,000. Approximately three awards are expected to be made under this initiative. There is no cost-sharing or matching requirement, making the program accessible to a wide range of applicants.

This opportunity represents a significant investment in advancing optical imaging technologies with broad implications for biomedical research. Interested applicants should monitor Grants.gov and related NIH announcements for updates and detailed guidance on submitting proposals.