The National Institutes of Health (NIH) invites applications for the "Stimulating Hematology Investigation: New Endeavors" (SHINE) R01 research program, under Funding Opportunity Number PAS-25-205. This program is a collaborative effort of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI) to promote innovative research in non-malignant hematology that addresses unmet needs in the field. The SHINE program funds investigator-initiated research on the molecular, cellular, and physiological aspects of hematologic conditions, aiming to support research that advances understanding, prevention, and treatment of blood-related diseases. Emphasis is placed on emerging research areas, which are updated periodically through related Notices linked to this funding opportunity.

Research areas currently prioritized by SHINE include the following topics: metabolic regulation of hematopoiesis, hematopoietic stem cell niche remodeling, erythrocyte maturation, hematopoietic stress responses, and the bone marrow microenvironment post-conditioning in non-malignant hematologic disorders. Two topics—macrophage roles in blood cell development and aging effects on hematopoiesis—are especially relevant, though February 5, 2025, will mark the final application deadline for these areas. SHINE’s scope is designed to evolve, focusing on timely, high-impact research areas identified through NIH-hosted workshops, which provide opportunities for researchers to engage in shaping future program directions.

Applications must include a Plan for Enhancing Diverse Perspectives (PEDP), detailing strategies to promote inclusivity and diversity in research, considering factors such as participant demographics, collaborative approaches, and the scientific expertise brought to the study. Applications lacking a PEDP will be considered incomplete. The plan will be evaluated alongside other scientific criteria, contributing to the overall merit assessment.

The SHINE program anticipates funding 5–8 awards, with a total budget of $2.5 million for FY 2025. Budgets are unrestricted, needing only to reflect actual project costs, and project periods may extend up to five years. Eligible applicants include higher education institutions, nonprofits, government entities, and certain foreign components associated with U.S. organizations. Foreign organizations are not eligible to apply as lead institutions.

Applicants should submit through Grants.gov by NIH's standard deadlines, which include February 5, June 5, and October 5 for new applications. Applications undergo a rigorous peer-review process, with considerations on the project’s significance, innovation, rigor, feasibility, and the qualifications of the investigative team. Additional considerations include human and vertebrate animal protections, resource authentication, and budget justification.

For specific questions on the SHINE program and guidance on aligning proposals with program priorities, applicants are encouraged to contact NIDDK, NIA, or NHLBI representatives listed in the NOFO. Regular updates on new research objectives will be provided in NIH's Guide to Grants and Contracts, keeping applicants informed of program shifts in line with evolving scientific needs.