The CDC Notice of Funding Opportunity (NOFO) RFA-IP-25-111 aims to support a research project designed to gather timely input from healthcare providers and the public on pressing immunization issues. The initiative focuses on conducting multiple scientifically rigorous surveys annually to inform national vaccine recommendations, enhance immunization coverage strategies, and address urgent concerns like vaccine shortages. Survey participants will include pediatricians, family physicians, OB/GYNs, pharmacists, nurse practitioners, and various public subpopulations such as parents of young children, rural residents, and individuals with chronic conditions.

The primary objective is to improve understanding of immunization attitudes, behaviors, and barriers among providers and the public. The NOFO aligns with Healthy People 2030 goals to increase vaccine coverage and reduce preventable diseases. Outcomes are expected to strengthen national immunization policies and preparedness for future public health emergencies. Awardees will develop surveys, analyze results, and disseminate findings to inform vaccine recommendations and public health strategies. Flexibility and capacity for rapid response to emerging issues are critical components.

The total funding available is $3,750,000 for a five-year performance period, with $750,000 allocated annually. Only one award will be granted. Eligible applicants include state and local governments, nonprofits, academic institutions, and other entities specified in the eligibility criteria. Foreign entities are not eligible to apply. Applicants must demonstrate the ability to conduct rapid surveys, ensure high response rates, and produce generalizable results. Proposals must be submitted through Grants.gov by February 6, 2025, and should include a detailed research strategy, budget, and project timeline.

Applications will be evaluated based on significance, investigator expertise, innovation, and approach, with an emphasis on methods for data collection, representativeness, and dissemination of findings. The review process includes scientific peer review and agency evaluation, considering both technical merit and alignment with program goals. The estimated award start date is September 1, 2025.

Recipients are required to provide annual progress and financial reports and adhere to CDC’s data-sharing policies. Compliance with human subjects' protections, data management plans, and institutional review board (IRB) approvals is mandatory. Findings must be broadly disseminated through publications, presentations, and reports to ensure integration into public health practice and policy. This NOFO is a critical step in enhancing vaccine program effectiveness and addressing the dynamic challenges of immunization in the U.S.