The U.S. Environmental Protection Agency, Region 10 (EPA), is issuing a Request for Applications (RFA) from eligible entities to improve the understanding of toxics and their effects on water quality in the Columbia River Basin by increasing the number, type, and scientific rigor of toxics monitoring projects in the Columbia River Basin through specific actions in three program priority areas: 1) characterization and spatiotemporal trend analysis; 2) pathway identification; and/or 3) novel methods and approaches. The Columbia River Basin Restoration Program (CRBRP) will assist Tribal, state, and local governments; nongovernmental entities, and others as they implement the 2010 Columbia River Basin Toxics Reduction Action Plan and the Lower Columbia River Estuary Plan - Comprehensive Conservation and Management Plan and conduct activities to support EPA national goals for the Columbia River Basin.