Schools are an ideal setting to foster healthy behaviors and to prevent and buffer the impact of adverse experiences. This NOFO aims to improve the health and well-being of youth by collecting and using school-based surveillance data at the state, territorial, or tribal nation level. Funding will support the collection and use of school-based surveillance data. These data, collected through the Youth Risk Behavior Surveillance System (YRBSS) and School Health Profiles (Profiles), will help assess needs to improve adolescent health, track behaviors and experiences over time, and understand the impact of programs and policies.