The Mathematical Sciences Research Institutes program (Funding Opportunity Number: 23-606) by the National Science Foundation (NSF) is designed to support institutions that promote research and development in mathematics and its interdisciplinary applications. The initiative seeks to fund institutes that serve as national resources, advancing the mathematical sciences through discovery, dissemination of knowledge, and fostering connections to other fields where mathematics plays a significant role. The program emphasizes collaboration, bringing together top mathematical minds to tackle critical and timely problems. Additionally, it aims to enhance the mathematical sciences' impact across various disciplines and expand the pool of researchers engaged in U.S.-based mathematical research.

The estimated total funding for this opportunity is $40,000,000, with anticipated awards ranging from $1,500,000 to $6,500,000. Up to eight awards are expected under this program. Proposals may be submitted by non-profit organizations (such as research laboratories, observatories, and professional societies) that are associated with educational or research activities, as well as accredited U.S.-based institutions of higher education, including two-year and four-year colleges. Multi-institutional consortia can also apply, but one entity must assume primary responsibility for managing the project. Proposals involving international branch campuses of U.S. institutions must justify the necessity of activities taking place outside the U.S.

The deadline for proposal submissions is March 14, 2029, with applications accepted until then. The program does not have a cost-sharing requirement, and it aims to support research institutes that not only advance mathematical sciences but also address interdisciplinary applications, thereby broadening the influence of mathematics in solving complex problems. The institutes supported through this grant will be expected to engage the mathematical community and contribute to increasing diversity and participation in mathematical sciences research.