The Office of Research Infrastructure Programs (ORIP) encourages resource-related research grant applications aimed at developing broadly applicable technologies, tools, and resources for validating animal models and enhancing rigor, reproducibility, and translatability of animal research. Proposed studies, models, resources, or technologies submitted under this Funding Opportunity Announcement (FOA) must either address research interests of multiple NIH Institutes and Centers (ICs), explore multiple organ systems, or be applicable to diseases and processes that impact multiple organ systems in order to align with ORIPs NIH-wide mission and programs. Applications should aim to enhance the rigor, reproducibility, and translatability of animal research through the development of technologies, tools, and resources that have significant impact across a broad range of research areas using animal models. Applications must demonstrate how the proposed resources and technologies impact rigor and reproducibility of animal studies. Applications for developing a limited quantity of resources are not suitable for this FOA.