he DOE SC program in High Energy Physics (HEP) hereby announces its interest in receiving interdisciplinary applications for open scientific research on Quantum Information Science (QIS) Enabled Discovery (QuantISED) to further the HEP mission to understand how the universe works at its most fundamental level. Successful applications will help define an exploratory program where innovative solutions for scientific discovery are developed and deployed to advance HEP science drivers and contribute to QIS research and technology for public benefit.The QIS subprogram within HEP has been developed over the last few years with a series of workshops, followed by funding opportunities in 2018 and 2019, and is aligned with a broader SC initiative in QIS and coordinated with various national and interagency QIS programs, including the National QIS Research Centers. Cross-cutting the traditional frontiers and thrusts of the HEP program, the QIS subprogram exploits the interdisciplinary nature of QIS and associated partnerships for exploratory, early-stage research aimed at high impact discoveries aligned with HEP science goals, but also driving developments in foundational QIS and related scientific and technology research areas.Such research is intended to create public benefit within HEPs Congressionally-authorized mission space by increasing human understanding of the physical universe and driving relevant developments of advanced technologies that support that mission.