The Stephen I. Katz Early Stage Investigator Research Project Grant (PAR-24-075) is a funding opportunity offered by the National Institutes of Health (NIH) aimed at supporting early-stage investigators (ESIs) who propose innovative research projects that represent a significant shift in research direction. This grant is intended to encourage ESIs to pursue novel scientific questions without relying on preliminary data, which are not permitted in the application. Instead, the project must clearly demonstrate a conceptual change in the investigator's research focus, with a separate attachment detailing the nature and significance of this change.

The grant is an R01 mechanism, typically used for health-related research and development based on the NIH’s broad mission areas, including various fields such as human genome research, cardiovascular diseases, cancer, diabetes, arthritis, mental health, child health, and others. While the grant does not allow clinical trials, it supports basic, applied, or translational research across a range of disciplines, aiming to advance scientific knowledge and health outcomes. The Katz Award encourages ESIs to explore new research avenues without the need to present preliminary results, fostering creativity and potentially transformative research.

Eligibility is broad, encompassing a variety of institutions, including public and private higher education institutions, government entities, nonprofits, small businesses, and tribal organizations. Eligible applicants also include specialized institutions like Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and other minority-serving institutions. While non-U.S. entities are not eligible to apply directly, foreign components may be included if they align with NIH guidelines.

The funding opportunity aims to level the playing field for early-stage investigators by removing the requirement for preliminary data, a common hurdle for less established researchers. The project scope should reflect a bold approach to address unanswered questions in the applicant's new field of interest. Since preliminary data are not allowed, the application must rely on the strength of the project's scientific rationale, significance, and innovation, as well as the applicant's capability to undertake the proposed work.

There is no specified award ceiling or floor, allowing applicants flexibility in proposing budgets that are appropriate to the project’s needs and duration. The grant does not require cost-sharing, which makes it accessible for ESIs who may not have additional funding sources. Applications must be submitted by December 28, 2026, providing an extended timeline for proposal development. This open period encourages ESIs to thoroughly plan and craft applications that align with the program’s emphasis on new research directions.