The Effectiveness Trials to Test Mental Health System Interventions (R61/R33 Clinical Trial Required) is a funding opportunity from the National Institutes of Health (NIH), aimed at supporting research to improve mental health service systems. This program focuses on testing interventions that address systemic issues within mental health services, such as access, equity, engagement, cost, management, and the quality of care. The goal is to improve clinical and functional outcomes by evaluating system-level interventions across various care settings like health systems, mental health clinics, schools, and child welfare or juvenile justice systems.

This funding opportunity follows the R61/R33 mechanism, consisting of two phases. The R61 phase involves feasibility and infrastructure development, laying the groundwork for the intervention's evaluation. The R33 phase then supports full-scale clinical trials to assess the effectiveness of these system interventions. The interventions may span multiple domains, such as structural, policy, organizational, and interpersonal, with a focus on improving service delivery and outcomes.

Eligible applicants include a wide range of organizations, including state and local governments, Native American tribal governments and organizations (both federally recognized and not), public and private higher education institutions, nonprofits, small businesses, and for-profit organizations. Specific eligibility is extended to various minority-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, and institutions serving Native Hawaiian or Native American populations.

The application deadline is October 15, 2027, with no specified award ceiling or floor. This grant aims to support initiatives that have a meaningful impact on the mental health system, contributing to enhanced care processes and outcomes. For further details and guidance, applicants can refer to the full NOFO or contact NIH Grants Information at grantsinfo@nih.gov.