The NSF CISE Directorate supports research and education projects that develop new knowledge in all aspects of computing, communications, and information science and engineering, as well as advanced cyberinfrastructure, through the following core programs: Division of Computing and Communication Foundations (CCF): Algorithmic Foundations (AF) program; Communications and Information Foundations (CIF) program; Foundations of Emerging Technologies (FET) program; and Software and Hardware Foundations (SHF) program. Division of Computer and Network Systems (CNS): Computer Systems Research (CSR) program; and Networking Technology and Systems (NeTS) program. Division of Information and Intelligent Systems (IIS): Human-Centered Computing (HCC) program; Information Integration and Informatics (III) program; and Robust Intelligence (RI) program. Office of Advanced Cyberinfrastructure (OAC): OAC Core Research (OAC Core) program; Proposers are invited to submit proposals in several project classes, which are defined as follows: Small Projects -- up to $600,000 total budget with durations up to three years: projects in this class may be submitted to CCF, CNS, and IIS only; Medium Projects -- $600,001 to $1,200,000 total budget with durations up to four years: projects in this class may be submitted to CCF, CNS, and IIS only; and OAC Core Projects -- up to $600,000 total budget with durations up to three years: projects in this class may be submitted to OAC only. A more complete description of these project classes can be found in SectionII. Program Descriptionof this document.