The United States Agency for International Development (USAID) is seeking applications from qualified entities for an anticipated cooperative agreement to implement the USAID/Ethiopia Health Security activity. Eligibility for this award is not restricted. The purpose of the USAID/Ethiopia Health Security Activity (HSA) is to reduce the impact of infectious disease outbreaks on morbidity and mortality through building a resilient One Health (OH) surveillance, diagnostics and workforce development capacities. The HSA will achieve this through strengthening Ethiopias capacity to detect infectious disease outbreaks early, supporting the subnational laboratory systems to diagnose resistant and zoonotic pathogens and building a OH workforce to respond to any emerging or re-emerging infectious disease outbreaks. The HSA will build on the lessons drawn from the USAID Ethiopias five years of experience in the sector including but not limited to Infectious Disease Surveillance (IDDS), Core Group Partners Project (CGPP) and Africa One Health University Network (AFROHUN). The expected outcomes will be evidence-based and will objectively be measured by the progress made in the countrys capacities to prevent, detect, and respond to emerging infectious and zoonotic diseases through a One Health approach.