In alignment with the CREST Program goals, through this solicitation, the CREST Program seeks to expand its geographic diversity and reach by explicitly calling for proposals led by and for efforts in Established Program to Stimulate Competitive Research (EPSCoR) jurisdictions. The U.S. National Science Foundation EPSCoR program pursues a mission to enhance the research competitiveness of targeted jurisdictions (state, territory or commonwealth) by strengthening science, technology, engineering and mathematics (STEM) capacity and capability through a diverse portfolio of investments from talent development to local infrastructure. For a list of EPSCoR jurisdictions visit https://new.nsf.gov/funding/initiatives/epscor/epscor-criteria-eligibility. EPSCoR CREST Center awards provide support to enhance the research capabilities of institutions through the establishment of centers that effectively integrate education and researchin EPSCoR jurisdictions. EPSCoR CREST Center awards promote the development of new knowledge, enhancements of the research productivity of individual faculty, and an expanded presence of students fromEPSCoR jurisdictionsin science, technology, engineering, and mathematics (STEM) disciplines. Successful EPSCoR CREST Center proposals will demonstrate a clear vision and integration of STEM research and education and will align with the mission of the Division of Equity for Excellence in STEM (EES) with respect to the development of a STEM workforce. EPSCoR CREST Centers are also expected to provide leadership by meaningfully involving the effortsofall individualsinSTEMat all levels. Centers are required to use evidence-based and innovative strategies to address workforce development issues, such as recruitment, retention, and mentorship of participantsfromEPSCoR jurisdictions. Successful proposals are expected to achieve national research competitiveness, broaden participation in STEM, and generate sustained, non-CREST funding from Federal, state, and/or private-sector sources. PhaseIandPhaseIIEPSCoR CRESTCenterAwards Both Phase I and Phase II EPSCoR CREST Center awards provide multi-year support for institutions that demonstrate a strong research base. Phase I EPSCoR CREST Center awards provide funding for five years of research on a specific NSF-supported topic.Institutions may submit a Phase II EPSCoR CREST Center proposal requesting funding to continue research in the same disciplinary area as the Phase I EPSCoR Center or may submit a Phase I proposalfocusedonadisciplinaryareathatis significantlydifferentfromthoseofthepreviousaward(s). EPSCoR CRESTPartnershipSupplements EPSCoR CREST Partnership Supplement requests are invited from current EPSCoR CREST Center recipients. Supplements support the establishment or strengthening of partnerships and collaborations with active CREST Centers and other nationally or internationally recognized research centers (including NSF-supported research centers), private sector research laboratories, K-12 schools, and/or informal science entities, including museums and science centers, as appropriate. Such partnerships and collaborations should aid EPSCoR CREST Centers quest in advancing knowledge and education on a research theme of national significance.