The NIH Mentored Quantitative Research Career Development Award (K25) is designed to support professionals with backgrounds in quantitative science and engineering (e.g., mathematics, statistics, computer science, physics, and engineering) in integrating their expertise with biomedical, behavioral, bioimaging, or bioengineering research. This program aims to develop a new cadre of scientists capable of addressing significant health challenges through innovative quantitative approaches. The award provides protected time for supervised research and career development activities, facilitating the transition to independence in NIH-relevant research.

Eligible applicants include U.S.-based institutions such as higher education institutions (public and private), nonprofits with or without IRS 501(c)(3) status, local and state governments, and certain tribal organizations. Foreign institutions are not eligible; however, foreign components may be included. Candidates must have a full-time position at a qualifying institution and dedicate at least 75% effort to the award activities. They must be U.S. citizens, non-citizen nationals, or lawful permanent residents. Candidates with advanced quantitative degrees and no substantial experience in biomedical research are encouraged to apply.

The K25 award includes funding for salaries, fringe benefits, and program-related expenses, such as tuition, research supplies, and travel. The total project period may not exceed five years. The proposed research plan should align with the candidate’s career development objectives, emphasizing the integration of quantitative skills into NIH-relevant research areas. Mentorship is a critical component, requiring candidates to identify experienced investigators to provide guidance and ensure structured career progression.

Applications should include detailed plans for research, mentorship, training in responsible conduct, and a description of the institutional environment. NIH emphasizes the importance of robust scientific methodology and plans for addressing variables like sex and biological diversity in research. Applications proposing clinical trials must include comprehensive trial designs and feasibility assessments.

Key dates include standard NIH submission deadlines for K-series awards, beginning June 12, 2024, for new and resubmission applications. Applications should be submitted electronically via NIH ASSIST or other designated platforms, and applicants must ensure compliance with the NIH Grants Policy Statement. Prospective candidates are encouraged to consult the IC-specific guidance and contact NIH staff for tailored advice.

Review criteria will assess the candidate’s potential for independence, the quality of the career development plan, research rigor, the mentorship team, and institutional support. Post-award responsibilities include submitting annual progress reports, financial reports, and ensuring compliance with NIH policies, such as data management and clinical trial registration.