The DOE SC program in Basic Energy Sciences (BES) announces a re-competition of the Energy Frontier Research Center (EFRC) program and encourages both new and renewal applications. Applications from multi-disciplinary teams will be required to propose discovery science and use-inspired basic research that addresses priority research directions and opportunities identified by a series of BES workshop and roundtable reports. The focus of the EFRC program is on fundamental scientific research, therefore applications to this FOA must not propose applied research and technology development activities. BES is soliciting renewal applications for basic science in three topical areas: 1) Transformative manufacturing, 2) Quantum information science (QIS), and 3) Environmental management. BES is soliciting new applications for basic science in two topical areas: 1) Co-design of materials and processes to revolutionize microelectronics and/or QIS fabrication, and 2) Environmental management.