The ADAPT Program, initiated by the Advanced Research Projects Agency for Health (ARPA-H), aims to transform cancer care through innovative research focused on developing adaptive strategies for treating the evolution of cancer. This program seeks to create a dynamic cancer treatment platform capable of detecting tumor changes, updating treatment plans accordingly, and evaluating these plans through a novel clinical trial design. The goal is to match each patient’s evolving cancer with the most effective therapy, thereby revolutionizing cancer care by integrating new science and medical approaches to improve survival rates for patients with metastatic cancer.