The purpose of the Cancer Immunoprevention Network (CIP-Net) is to support a deeper understanding of basic mechanisms of immunoprevention, discover novel immunoprevention strategies, and foster a community of cancer immunoprevention researchers. ?The UG3/UH3 research projects will enable de novo discovery of immune pathways, immunoprevention mechanisms, or investigation of new vaccine or immunomodulatory targets or agents. Applicants responding to this FOA must apply for both the UG3 and UH3 phases together in a single application. Achievement of the UG3 milestones will be necessary for transition to the UH3 phase. UH3 phase may be awarded after administrative review of the UG3 milestones. Provided these milestones are achieved, UH3 phase may continue.