The National Institutes of Health (NIH) has announced the reissued Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed), supporting small-scale research projects at institutions that prioritize undergraduate education. This program aims to enhance the research environment at these institutions, provide hands-on research opportunities for undergraduate students, and promote their engagement in biomedical research fields. Projects must involve undergraduates in meaningful research activities, with a majority of the research team composed of undergraduate students.

Eligible institutions must be public or non-profit private schools awarding baccalaureate degrees in biomedical sciences. To qualify, non-health professional components of the institution must not have received more than $6 million annually in NIH funding in four of the past seven fiscal years. Health Professional Schools and Colleges, or components leading to health professional degrees, are excluded from eligibility. Eligible projects may include multiple investigators but must demonstrate a significant impact on the applicant institution's research capabilities and undergraduate involvement.

The program provides up to $375,000 in direct costs for a maximum three-year project period. Awards are granted based on NIH appropriations and the number of meritorious applications. Proposals may include preliminary or published data to establish the project's scientific foundation. Applications must also detail how the research will strengthen institutional capacity, actively engage undergraduates, and support the broader goals of enhancing diversity and equity in biomedical research.

Applicants must submit their proposals through NIH systems such as ASSIST, eRA Commons, or Grants.gov, adhering strictly to NIH guidelines. Required documents include a research strategy, detailed budget, student engagement plan, and a letter from the institution’s Provost verifying eligibility. Review criteria will evaluate the scientific merit, institutional impact, and the extent of undergraduate involvement. Proposals must demonstrate compliance with NIH policies, including data sharing and safe laboratory practices.

Key dates for submission align with NIH’s standard grant cycles, with the first due date for new and resubmission applications on June 25, 2024. Applicants are strongly encouraged to consult NIH scientific program contacts for pre-application guidance to ensure alignment with specific NIH institutes’ interests. Final decisions will be based on peer review, relevance to NIH program priorities, and availability of funds.

Successful applicants will be required to submit annual progress reports and final deliverables documenting undergraduate research participation, outcomes for students (e.g., graduate education or employment in biomedical fields), and research products such as publications and presentations. Institutions are also expected to comply with NIH’s policies on nondiscrimination, integrity, and data management. Further details and application instructions are available in the full funding opportunity announcement on the NIH website.