The National Heart, Lung, and Blood Institute (NHLBI) intends to publish a Request for Applications (RFA) seeking applications for a multisite clinical trial that will test a screening approach to identify coronary atherosclerosis and test interventions to reduce the progression of coronary atherosclerosis. There will be only one award for this RFA. The planned RFA will utilize the UG3/UH3 activity code with details provided below. The planned RFA will support a Clinical Coordinating Center (CCC) and will run in parallel with a companion RFA for a collaborating Data Coordinating Center (DCC) application.This RFA will accept only an application that is part of a collaborative pair of applications. The pair must include one application to the CCC UG3/UH3 Notice of Funding Opportunity (NOFO) plus one application to the companion DCC U24 NOFO.Both a CCC application and a collaborating DCC application must be submitted on the same due date for consideration by NHLBI. CCC (UG3/UH3) applications submitted without a collaborative DCC (U24) application will be deemed incomplete and will not proceed to review. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The planned RFAs are expected to be published in Summer 2024 with an expected application due date in Fall 2024.