The NIH Mentored Quantitative Research Career Development Award (K25) aims to support professionals with quantitative science and engineering backgrounds in applying their expertise to health and disease research. It is tailored for researchers with little or no prior experience in biomedical or behavioral research and does not support candidates leading independent clinical trials. Instead, applicants may propose participation in clinical trials led by a mentor or co-mentor. This Notice of Funding Opportunity (NOFO) enables a transition to independence for quantitative researchers, fostering their development in NIH-relevant biomedical and behavioral research areas.

Eligible applicants include U.S. institutions such as higher education organizations, nonprofits, for-profit organizations, state and local governments, and eligible tribal organizations. Candidates must be U.S. citizens, non-citizen nationals, or lawful permanent residents. Individuals with advanced quantitative degrees and a demonstrated commitment to research are encouraged to apply. Applicants must commit 75% effort to the program, with the remaining time for compatible activities that support their career development. They must also identify a mentor or mentoring team to guide their research and career progression.

Funding provides salary support and research-related expenses, including tuition, supplies, travel, and statistical services. The total project period cannot exceed five years, with award budgets tailored to individual research and career development plans. Institutions must demonstrate a strong commitment to the candidate's development, providing necessary resources and infrastructure. The application must detail a systematic plan for research, mentorship, and institutional support, emphasizing the integration of quantitative skills into biomedical research.

The review process evaluates candidates on their potential for independence, the rigor of the research plan, the quality of the mentorship, and the institutional commitment to the applicant’s career development. Additional considerations include the inclusion of underrepresented groups and compliance with human and animal research ethics. Successful applications will demonstrate alignment with NIH goals and a clear trajectory towards establishing independent research careers in quantitative biomedical or behavioral science.

Applications must be submitted electronically through NIH-designated systems, adhering to NIH’s detailed application instructions. Key dates align with NIH’s standard deadlines for K-series awards, beginning June 12, 2024. Award recipients must submit annual progress reports, final closeout reports, and comply with NIH’s data sharing and other policy requirements.

This program offers a valuable opportunity for quantitative scientists to transition into impactful health-related research, leveraging their expertise in new interdisciplinary contexts. Interested applicants are encouraged to review institute-specific guidelines and consult NIH staff for application alignment with program goals.