The PRMRP Investigator-Initiated Research Award (IIRA) supports fundamental research studies that will make an important contribution toward research, patient care, and/or quality of life for a disease or condition related to one of the FY24 PRMRP Topic Areas and one of the FY24 PRMRP Strategic Goals. This award mechanism is intended to support basic research that is exploratory in nature and seeks to further or validate preliminary findings for short- or long-term impact. Research projects may focus on any stage of basic laboratory research, ranging from fundamental research for the generation of knowledge, hypothesis, or models, to expansion of mature data.The rationale for a research idea may be derived from a laboratory discovery, population-based studies, a clinicians first-hand knowledge of patients, or anecdotal data. The project should include a well-formulated testable hypothesis based on existing evidence. Applications must include relevant preliminary data that support the rationale and feasibility for the proposed study. These data may be unpublished or from the published literature.This award mechanism is not intended to support translational research. Applicants seeking funding for projects that have progressed beyond the realm of basic research should consider one of the other FY24 PRMRP program announcements being offered. For information about these award mechanisms, see Section II.A.1, FY24 PRMRP Research Development Pipeline.