The Office of Science (SC) seeks applications for fundamental research in fields supported by SC to build research capacity at institutions historically underrepresented in the SC portfolio, i.e. non-R1 minority serving institutions (MSIs)[1],[2] and non-R1 emerging research institutions (ERIs).[3] This FOA aims to build research capacity, including infrastructure and expertise at these institutions, through mutually beneficial relationships between applicants and DOE national laboratories, SC scientific user facilities, or R1 MSI/ERIs. A list of institutions and their designations is provided at https://science.osti.gov/grants/Applicant-and-Awardee-Resources/Institution-Designations. [1] The Carnegie Classification of Institutions of Higher Education can be found at https://carnegieclassifications.acenet.edu. A list of institutions with very high research activity (R1 institutions) is available at https://carnegieclassifications.acenet.edu/institutions/?basic2021__du%5B%5D=15. [2] MSI designations are based on the Department of Education eligibility matrix (https://www2.ed.gov/about/offices/list/ope/idues/eligibility.html). Eligible MSIs are listed as Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), Alaska Native and Native Hawaiian Serving Institutions (AANHs), Hispanic Serving Institutions (HSIs), Native American Serving Non-Tribal Institutions (NASNTI), Predominantly Black Institutions (PBIs), Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). For the purposes of this FOA, institutions marked in the eligibility matrix as either being eligible to receive funding or as receiving funding will be considered an MSI. [3] Emerging research institution was defined in the CHIPS and Science Act of 2022. Federal research expenditures are based on the National Science Foundations Higher Education Research and Development Survey: Fiscal Year 2021 (https://ncses.nsf.gov/surveys/higher-education-research-development/2021).