The "Emerging Mathematics in Biology" (eMB) program, identified as opportunity number 25-509, is a discretionary grant opportunity from the National Science Foundation (NSF). This program is focused on advancing mathematical biology by supporting integrative research that applies or develops innovative mathematical theories, techniques, and approaches to address significant and complex biological questions. The program encourages collaboration between mathematicians and biologists to develop mathematical solutions that enhance understanding across biological scales, from molecular and cellular levels to ecosystems and evolutionary dynamics.

The purpose of the eMB program is to stimulate new mathematical approaches and models that can be applied to critical biological and public health issues. Projects are expected to involve traditional mathematical tools and methods or to develop new mathematical theories. Areas of interest include foundational mathematics in artificial intelligence, deep learning, and machine learning, with an emphasis on creating explainable AI or gaining mechanistic insights into biological processes. The goal is to use mathematics to explore dynamic, heterogeneous systems in biology and make breakthroughs in understanding complex biological phenomena.

The NSF expects to make approximately 15 awards under this program, with an estimated total funding amount of $6,000,000. Specific award ceilings and floors are not provided, but the funds will be distributed to institutions based in the United States. Eligible applicants include accredited two- and four-year institutions of higher education located within the United States. Proposals may also involve international campuses of U.S. institutions, provided there is a clear justification of the benefits and a rationale for activities occurring at international sites.

Applications are due by March 3, 2025, with a closing date for archives on April 1, 2026. Interested applicants are advised to consult NSF Publication 25-509 for detailed program information. For technical assistance with application submission or inquiries regarding the announcement, applicants may contact NSF grants support at grantsgovsupport@nsf.gov.