The Strategic Prevention Framework – Partnerships for Success for Communities and Tribes (SPF-PFS) program, administered by the Substance Abuse and Mental Health Services Administration (SAMHSA), aims to prevent and reduce substance use and its associated problems. This grant supports community-based initiatives that strengthen protective factors, reduce risk factors, and promote overall resilience and well-being. It specifically encourages the implementation of evidence-based, evidence-informed, and community-defined prevention strategies targeting underserved communities disproportionately impacted by substance use disorders (SUD). Applicants are expected to use public health data to prioritize prevention efforts addressing issues such as underage drinking, vaping, opioids, and other emerging substance concerns.

The program's funding ranges from $250,000 to $600,000 per year, depending on the population size of the community or tribe served. The project period can last up to five years, contingent on meeting program goals, compliance, and the availability of funds. The SPF-PFS initiative utilizes SAMHSA’s Strategic Prevention Framework, which includes assessment, capacity building, planning, implementation, and evaluation phases. It also emphasizes cultural competence and sustainability in program design and delivery. Communities and tribes must identify up to three priority substance use concerns based on a data-driven assessment and establish measurable objectives to track progress.

Eligibility is restricted to domestic public and private nonprofit entities, including community-based organizations, tribal organizations, institutions of higher education, and local governments. Applicants must demonstrate a focus on underserved populations and may earn bonus points if over 50% of the population served falls into this category. Current SPF-PFS recipients may apply only if the proposed project targets different populations or geographic areas. No cost-sharing or matching funds are required for this grant.

Applications must include a project narrative of no more than 10 pages, detailing the population served, planned strategies, and measurable goals. Supporting documents, such as letters of commitment, data collection protocols, and biographical sketches, are also required. A comprehensive evaluation plan outlining how data will be collected, reported, and used for program improvement is mandatory. Specific quarterly and annual reports, including needs assessment, implementation, and evaluation plans, must be submitted within specified timelines.

The deadline for application submission is March 18, 2025, with the program expected to begin by September 30, 2025. Applications must be submitted electronically via Grants.gov, and organizations must ensure they are registered in SAM.gov and eRA Commons. SAMHSA plans to notify successful applicants through a Notice of Award, with comprehensive reporting and participation in evaluation activities required throughout the project lifecycle.