The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. The EFRI Biocomputing through EnGINeering Organoid Intelligence (BEGIN OI) solicitation supports foundational and transformative research to advance the design, engineering, and fabrication of organoid systems that are capable of processing information dynamically while interfacing with non-living systems. This solicitation will be coordinated with the Directorate for Biological Sciences (BIO), the Directorate for Computer and Information Science and Engineering (CISE), the Directorate for Mathematical and Physical Sciences, and the Directorate for Social, Behavioral, and Economic Sciences (SBE). The EFRI program seeks proposals with potentially transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with strong potential for long term impact on national needs or a grand challenge. The proposals must also meet the detailed requirements delineated in this solicitation. INFORMATIONAL WEBINAR: The Emerging Frontiers and Multidisciplinary Activities (EFMA) Office will host an informational webinar in November 2023 to discuss the EFRI FY 2024/25 solicitation and to answer questions. Details on how to join this webinar will be posted on the EFRI websiteand Solicitation Website.