The HEAL Initiative Advanced Postdoctoral-to-Independent Career Transition Award in Pain and SUD Research, under NIH’s K99/R00 pathway, aims to support postdoctoral researchers in the transition to independent, tenure-track positions in research fields focused on pain and substance use disorder (SUD). The award is structured in two phases: a mentored K99 phase offering up to two years of support for postdoctoral research training, followed by a three-year R00 phase for independent research. Both stages aim to foster rigorous scientific inquiry aligned with the NIH’s goals to improve pain management and address the opioid crisis through the HEAL Initiative. Specifically, this funding is reserved for basic experimental studies involving humans and aligns with NIH’s definition of clinical trials while meeting criteria for basic research.

This funding opportunity is directed towards postdoctoral researchers with no more than four years of relevant experience, focusing on candidates who need additional mentoring to become competitive for tenure-track roles. Ideal applicants should outline a detailed, phased research plan demonstrating how their K99 work will lead to an independent research program during the R00 phase. Studies eligible for funding involve human participants, prospectively assigned to experimental conditions to assess biomedical or behavioral outcomes, aimed at gaining fundamental scientific insights rather than immediate practical applications. This focus includes the advancement of research methodologies and understanding biological or behavioral mechanisms related to pain and addiction.

The total project period can extend up to five years, with a maximum of $75,000 per year for salary and $20,000 for research costs during the K99 phase, with exceptions for licensed medical practitioners who may receive up to $125,000 in annual salary support. The R00 phase budget provides up to $249,000 per year, covering salary, research costs, and applicable indirect expenses. The application must clearly demonstrate institutional support, a structured career development plan, and a timeline for achieving independence. Institutional commitment to the candidate’s transition to independence is required, including assurances for a minimum of 75% dedicated effort to the proposed research.

Applications are accepted from public and private higher education institutions, nonprofits, small businesses, and other eligible organizations, including federally recognized Native American tribes. U.S. institutions are eligible, although foreign components may be included if justified. Applicants must submit through NIH's ASSIST system or Grants.gov by key dates in February, June, and October each year. Applications undergo a peer-review process assessing scientific merit, feasibility, and alignment with HEAL Initiative priorities.

Review criteria encompass the candidate’s research record, the proposed career development plan, and the mentor’s qualifications. Reviewers evaluate the likelihood of the candidate’s success in attaining an independent position and the project’s potential impact on advancing pain and SUD research. The selection process prioritizes applications that demonstrate robust research strategies, an environment conducive to career development, and a strong mentoring team. Adherence to NIH's Responsible Conduct of Research and inclusion of diverse populations in studies are mandatory.

For post-award administration, the transition to the R00 phase requires the candidate to secure an independent, tenure-track faculty position and demonstrate institutional commitment comparable to other newly appointed faculty. The R00 application must include updated research plans and documentation of institutional support. NIH strongly encourages consulting program officials before submission to ensure responsiveness to HEAL Initiative priorities and requirements.