In keeping with the wishes of Michael and Sarah Benedum, the Claude Worthington Benedum Foundation is a regional philanthropy focusing on West Virginia and Southwestern Pennsylvania. The Foundation generally invests two-thirds of its grant dollars in West Virginia and one-third in Southwestern Pennsylvania.

The Foundation serves the entire state of West Virginia. In Southwestern Pennsylvania, the service area includes Allegheny, Washington, Greene, and Fayette Counties. This four-county area is a natural connector between Pittsburgh and West Virginia and contains rural communities that may benefit from the Benedum Foundation’s experiences in West Virginia. However, the Foundation recognizes that economic regions do not follow political boundaries, and therefore, the Foundation both encourages projects that cross state lines, and supports economic initiatives that benefit the multi-state economy centered on Pittsburgh.

The Foundation makes grants in two program areas that span both states: Education and Economic Development. In addition, the Foundation supports Community Development and Health grants programs in West Virginia, and in Southwestern Pennsylvania supports the major performing arts organizations within the Cultural District.