The National Institutes of Health (NIH) Office of Data Science Strategy (ODSS), with other NIH Institutes and Centers (ICs), intends to promote an initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for established biomedical data repositories or knowledgebases. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NIH intends to continue the Database and Knowledgebase program beyond the January 25, 2023, receipt date of the current FOAs (PAR-23-078 and PAR-23-079). This new FOA will support established biomedical data repositories and knowledgebases. This Notice of Intent to Publish (NOITP) is being provided to allow potential applicants time to develop meaningful community engagement, collaborations, and NIH consultations to submit applications for responsive data repositories and knowledgebases as trans-NIH data resources. The FOA is expected to be published in Spring 2023 with an expected application due date in Fall, 2023. This FOA will utilize the U24 activity code. Details of the planned FOAs are provided below.