Sustainable chemistry produces compounds or materials with intentional design, manufacture, use, and end-of-life management. Across their lifecycle, sustainable chemicals promote circularity, meet societal needs, and contribute to economic resilience. The introduction of more sustainable chemical products, processes, and technologies are needed to address emerging and growing challenges and opportunities for the economy, climate action, and environmental justice. This Request for Applications (RFA) is soliciting research for data, methods, and systems that lead to actionable, scalable change toward chemistry, chemicals, and products that support sustainable chemistry.