The LRP seeks to improve quality of life of persons with lupus using an intervention at the individual and/or health care system level. This effort is supported through two related, but separate, award mechanisms, the LRP TVDA and the LRP Transformative Vision Award (TVA).The TVDA is intended to provide support to conduct pilot studies that will generate preliminary data and demonstrate feasibility for achieving the aims of a future TVA project.The TVA supports applications that will fulfill an extraordinary vision for dramatically improving the quality of life of persons with lupus in the near term using an intervention at the individual and/or health care system level.Applicants are not required to be awarded a TVDA to submit a TVA application.Examples of suitable LRP TVDA preliminary studies would include development and optimization of an intervention, intervention safety studies, or refinement of trial design.The CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.