The goal of the Activity is to improve the health, well-being, and protection of children and adolescents (and their families) living with, affected by, and vulnerable to HIV through high-impact service delivery and social service system strengthening to sustain an effective response for children, adolescents, and their families through locally led solutions in North West Province. The United States Agency for International Development (USAID) is seeking applications for acooperative agreement from qualified entities to implement the Children, Adolescents, andFamilies in the HIV Epidemic in North West Province Activity. Subject to funding availabilityand at the discretion of the Agency, USAID intends to provide up to $20 million in total USAIDfunding over a five (5) year period. Eligibility for this award is restricted to local entities (seeSection C.1 of this notice of funding opportunity (NOFO) for eligibility requirements of localentities). USAID encourages applications from potential new local partners. The Activity will beimplemented in the North West Province of South Africa.