This 5-year projects purpose is to continue collaboration with counterparts in China to reduce the threat of infectious disease transmission, in China, the U.S. and the world. This collaboration contributes to enhancing the technical collaboration, scientific exchange, and effective communication to promote health through trusted and robust partnerships between U.S. CDC and counterparts in China. The program has three broad goals: 1) strengthen public health systems and workforce capacity, 2) decrease the burden of TB, and 3) reduce influenza morbidity and mortality and enhance preparedness for pandemic threats. Activities may include joint investigations and monitoring of disease outbreaks, piloting innovative public health interventions, translating programmatic success to practice and policy, working in third countries to jointly respond to a public health emergency, and promoting rapid and transparent dissemination of public health data. This collaboration strives to leverage the expertise in China to share knowledge and evidence-based science for a bi-lateral exchange that mutually benefits the U.S. and China. By identifying governmental, non-governmental, multilateral, and private sector organizations in China, the partnership builds sustainable expertise and capacity in global health security and public health systems. Depending on funding availability and priorities, the specific infectious disease entities to be addressed can change over the period of performance.