The "CCRP Initiative: Chemical Threat Agent-induced Pulmonary and Ocular Pathophysiological Mechanisms" (RFA-ES-24-005) is a funding opportunity offered by the National Institutes of Health (NIH) to support research on understanding the mechanisms of toxicity caused by chemical threat agents that affect the eyes and lungs. This initiative is part of the Countermeasures Against Chemical Threats (CounterACT) program within the Chemical Countermeasures Research Program (CCRP). The goal is to identify potential molecular and genetic targets that can reduce the acute effects of these chemical threats and pave the way for the development of therapeutic countermeasures. The R01 grant mechanism used in this opportunity does not allow for clinical trials.

Eligible applicants for this grant include a diverse range of entities such as public and private institutions of higher education, state and local governments, Native American tribal organizations, nonprofits, small businesses, and for-profit organizations. Minority-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs), are also eligible. While foreign institutions are not eligible to apply directly, foreign components can be included if they adhere to NIH guidelines.

The program encourages research aimed at elucidating the biological and molecular pathways involved in chemical-induced lung and eye damage. The focus is on identifying potential therapeutic targets that could be used to mitigate the harmful effects of exposure to toxic chemicals, such as industrial chemicals, pesticides, or chemical warfare agents. The discoveries made under this program can inform future efforts to develop countermeasures that protect public health during chemical emergencies.

Applications should clearly define the chemical agents being studied, the mechanisms by which they induce toxicity, and the potential intervention strategies being explored. The research should be hypothesis-driven and may include studies at the cellular, molecular, or whole-organism levels. The initiative aims to foster innovative approaches that can lead to significant advancements in understanding and mitigating the impacts of chemical threats.

The application deadline is September 23, 2026, allowing for a substantial period to prepare comprehensive proposals.