This funding opportunity, CDC-RFA-DP-25-0024, is designed to support public health efforts in the U.S. territories and freely associated states to address chronic diseases through evidence-based and culturally tailored strategies. Chronic diseases are a significant health burden, and this grant aims to reduce disability and death rates by targeting modifiable risk factors such as tobacco use, diabetes, and oral health disparities. The program recognizes the unique challenges faced by island communities, including limited infrastructure, geographic isolation, and diverse cultural contexts.

The initiative is divided into two components. The mandatory Core Component focuses on integrated strategies to reduce tobacco use, manage diabetes, and improve related health outcomes. The optional Oral Health Component addresses oral health disparities through interventions such as preventive dental services and infection control in dental settings. Applicants for the Oral Health Component must also apply for the Core Component. The funding, distributed over a five-year period, totals $17,450,000, with individual annual awards averaging $475,000 for the Core Component and $200,000 for the Oral Health Component.

Eligible applicants include a wide range of organizations such as state and local governments, nonprofits, institutions of higher education, tribal organizations, and small businesses. Applicants must demonstrate their capacity to access and submit relevant health data and provide proof of location within the eligible territories or freely associated states. Collaboration with local health departments and community stakeholders is emphasized to ensure the success and sustainability of the initiatives.

Applications must include a project narrative, work plans, budget justifications, and supporting documentation such as an organizational chart, staffing plans, and letters of support. A detailed evaluation and performance measurement plan is also required. The deadline for submission is January 15, 2025, with the project expected to start on March 31, 2025.

The review process assesses applicants on their background and approach, organizational capacity, and plans for evaluation and performance measurement. Applicants must address health disparities and propose feasible strategies to achieve measurable outcomes. Emphasis is placed on building collaborations, leveraging resources, and aligning activities with national health priorities.

For further guidance, prospective applicants can attend an informational call on December 3, 2024. Detailed instructions for application submission and post-award requirements, including reporting and compliance, are provided in the NOFO. This funding opportunity supports the CDC’s mission to improve public health and promote equity in vulnerable communities.