The NSF’s Mathematical Biology Program supports research across the mathematical sciences with a focus on projects that are highly relevant to biological sciences. Proposals must emphasize the integration of mathematical innovation with biological applications, presenting both biological significance and a robust collaboration between mathematics and biology. Key areas of interest for this program include developing mathematical theories, methodologies, and tools that may traditionally belong to other disciplines but can drive advancements in biological science. In cases where a proposal could fit within multiple NSF programs, applicants are encouraged to reach out to program officers for guidance to streamline the submission and review process.

Collaborations are a priority in the Mathematical Biology Program, particularly with other programs within NSF’s Directorates for Biological and Mathematical Sciences. Proposals suited for joint consideration will undergo evaluation by multiple NSF programs. Applicants are encouraged to consult with relevant program officers for interdisciplinary projects to determine eligibility and support options. This initiative also accommodates Research in Undergraduate Institutions (RUI), with specific guidelines available through the RUI solicitation, as these proposals may differ from the general NSF Proposal & Award Policies & Procedures Guide (PAPPG).

Additionally, the program offers options for EArly-concept Grants for Exploratory Research (EAGER) and Rapid Response Research (RAPID) proposals, which allow for innovative or urgent studies that address immediate needs within the field. Potential applicants must consult with the program directors before submitting these types of proposals. Supplemental funding requests for current award holders should similarly be discussed with a program director to ensure alignment with the program’s priorities and requirements.

For conferences and workshops related to mathematical biology, researchers must submit proposals at least eight months before events held in the U.S. or twelve months for international events. These proposals should refer to the “Conferences and Workshops in the Mathematical Sciences” guidelines for a detailed overview of proposal requirements, which includes specific formatting and content expectations. This preparatory window ensures ample time for review and alignment with NSF’s objectives for outreach and scientific exchange.

Proposals to the core Mathematical Biology Program have an annual submission window starting on October 1 each year, with a deadline by October 14. If resubmitting a revised proposal previously declined, applicants must wait at least twelve months from the prior submission date. Additional solicitations, such as the Emerging Mathematics in Biology (eMB) and the Faculty Early Career Development Program (CAREER), may have separate deadlines, and conference or workshop proposals are subject to the eight- and twelve-month submission requirements, depending on location.

To apply, researchers should submit proposals to Program Document 22-7334 via Research.gov, following the guidelines in the NSF PAPPG, or through Grants.gov as per the NSF Grants.gov Application Guide. These resources detail the application process and include submission tips to support adherence to NSF’s requirements and enhance the potential for successful review.