The NIH’s Human Virome Program (RFA-RM-24-009) seeks to fund the development of novel tools, models, and methodologies that will significantly advance the study of the human virome. This funding opportunity addresses the current technological limitations in characterizing the human virome— the collective of viruses in the human body—and aims to enhance understanding of its role in health and disease. Despite advances in sequencing and computational analysis, challenges persist in accurately identifying, annotating, and analyzing the vast array of viruses in the human virome. Successful applicants will contribute innovative technologies to enable robust interrogation and functional characterization of virome components.

The grant will be issued as a cooperative agreement, allowing NIH to collaborate closely with awardees. Funding is discretionary, with an award ceiling of $350,000. The grant requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be a key component of the peer review process. Applicants must propose strategies to incorporate a variety of perspectives within their project plans, fostering inclusivity in research approaches and contributions.

Eligible applicants include a broad spectrum of entities such as higher education institutions, nonprofits, for-profit organizations (excluding small businesses), government agencies, tribal organizations, and certain community-based organizations. This includes specialized groups like Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs). Notably, while non-U.S. entities cannot apply as lead organizations, foreign components are allowed under U.S. organizations as specified by NIH policies.

Applications are due by February 27, 2025, and the program will be archived on April 4, 2025. This opportunity is focused on fostering innovative research tools that could transform virome research and ultimately enhance our understanding of viral influences on human health. Detailed guidance and submission information are available through the NIH’s official grant announcement. Applicants are encouraged to contact NIH Grants Information for further assistance as needed.