Neuropathological Interactions Between COVID-19 and ADRD (R01 - Clinical Trial Not Allowed)
The "Neuropathological Interactions Between COVID-19 and ADRD" grant aims to fund research that investigates how COVID-19 affects the brain and cognitive outcomes in models with Alzheimer's Disease and related dementias (AD/ADRD), how it accelerates these conditions in early stages, and how it potentially increases the risk for future AD/ADRD.
Description
This NOFO will solicit R01 applications that propose studies in animal, cell culture, and/or human tissue models to elucidate the mechanisms by which COVID-19 interacts with and/or modulates AD/ADRD-relevant phenotypes. Either the model itself or the experimental readouts will be required to incorporate AD/ADRD risk factors, pathologies, or relevant comorbidities. To this end, proposals can focus on one or more of the following: - Mechanistic studies that address how COVID-19 impacts CNS pathology and cognitive outcomes when AD/ADRD pathology is already present (for example, in a model of AD/ADRD). - Mechanistic studies that address how COVID-19 accelerates AD/ADRD pathology and cognitive deficits in a prodromal model (early phase, pre-symptomatic). - Mechanistic studies that address how COVID-19 predisposes for AD/ADRD and/or interacts with relevant comorbid conditions and risk factors (cellular mechanisms that could potentially increase the risk for future AD/ADRD).