Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding the nervous system at all levels, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines to accelerate the understanding of nervous system structure and function, mechanisms underlying nervous system disorders, and computational strategies used by the nervous system. Through the CRCNS program, the participating funding organizations support collaborative activities that span a broad spectrum of computational neuroscience research, as appropriate to the missions and strategic objectives of each agency. Two classes of proposals will be considered in response to this solicitation: Research Proposals describing collaborative research projects, and Data Sharing Proposals to support sharing of data and other resources. Domestic and international projects will be considered, including proposals seeking parallel international funding. As detailed in the solicitation, opportunities for parallel funding are available for bilateral US-German, US-French, US-Israeli, US-Japanese, and US-Spanish projects, and multilateral projects involving the United States and two or more CRCNS partner countries (see Section VIII of the solicitation for country-specific limitations). Collaborating PIs from outside of the United States are referred to Section VIII of this solicitation for further instructions from the appropriate partner funding agency. Questions concerning a particular project's focus, direction, and relevance to a participating funding organization should be addressed to the appropriate person in the list of agency contacts in Section VIII of the solicitation. NSF will coordinate and manage the review of proposals jointly with participating domestic and foreign funding organizations, through a joint panel review process used by all participating funders. Additional information is provided in Section VI of the solicitation.