The State Opioid Response (SOR) Grants aim to address the public health crisis caused by escalating opioid misuse, opioid use disorder (OUD), and opioid-related overdose across the nation. The grants are intended to increase access to FDA-approved medications for OUD treatment, support the continuum of prevention, harm reduction, treatment, and recovery support services for OUD and other concurrent substance use disorders, and support care for stimulant misuse and use disorders. Eligible applicants are Single State Agencies (SSAs) and territories. Applications are due by July 1, 2024, and the anticipated total available funding is $1,480,500,000 with up to 59 awards expected. The project length is up to three years, and no cost sharing or matching is required.