This funding opportunity is a call for applications to establish and operate a Manufacturing USA institute focused on the use of artificial intelligence (AI) to strengthen the resilience of U.S. manufacturers. Through this competition, NIST expects to select an applicant or applicant team most capable of establishing and leading a public-private partnership that will integrate expertise in AI, manufacturing processes, and supply chain networks to conduct applied R projects that address industry-wide needs for innovation leading to greater resilience of manufacturing systems. The AI for Resilient Manufacturing (AI MFG) Manufacturing USA (AI MFG USA) institute is also expected to cultivate the development of a world-leading workforce needed to deploy institute-developed AI technologies into industrial use. The award will provide financial resources to establish the AI MFG USA institute, conduct startup activities and operate a national effort to accelerate manufacturing innovation and increase U.S. global competitiveness.