The Military Health System Research Program (MHSRP) provides research grants on topic areas directed by the Office of the Assistant Secretary of Defense for Health Affairs (OASD (HA)) and the Leadership of the Defense Health Agency (DHA). The intent of MHSR is to foster research capability and capacity that supports the Military Health System (MHS) as a learning health system and to mature as an integrated health system focused on Ready Reliable Care that improves outcomes for patients, staff, and the enterprise. The MHSRP funds research that examines factors that affect the enterprise in terms of economics/cost, quality, outcomes, variation, policies, and how they impact health readiness. The goal is to identify and characterize the factors that influence the efficiency and effectiveness of MHS care delivery. Knowledge obtained from this research should support evidence-based policy and decision-making at the strategic and front-line levels. This Notice of Funding Opportunity (NOFO) seeks rigorous collaborative health system research that has the potential to innovate military and civilian health care. The goal is to enhance data-driven evidence that optimizes the MHS delivery of health care and improves the health of beneficiaries. This NOFO is intended to solicit Intramural and Extramural Military Health System Research aligned with DHA priority research areas.