The Health Resources and Services Administration (HRSA) HIV/AIDS Bureau (HAB) Ryan White HIV/AIDS Program (RWHAP) Part F Special Projects of National Significance (SPNS) is offering funding for the Street Medicine Interventions for People with HIV who are Unsheltered - Demonstration Sites initiative (HRSA-25-056). This program is designed to support 10 demonstration sites that will collaborate with an associated Capacity Building Provider (HRSA-25-055) and Evaluation Provider (HRSA-25-057). The program aims to develop, evaluate, and disseminate street medicine interventions for unsheltered individuals living with HIV who are out of care or not consistently engaged in healthcare services.

Street medicine is the direct provision of health services in unsheltered environments, including streets, under bridges, and other public spaces. The goal of this initiative is to improve health outcomes and quality of life for people with HIV by implementing client-centered, low-barrier interventions. The funded sites will work to re-engage individuals in HIV care, provide access to antiretroviral therapy, monitor viral suppression, and address additional health and social service needs. The project will emphasize equity, inclusivity, and stigma reduction, while integrating an interdisciplinary team of medical, mental health, substance use, and social service providers.

HRSA has allocated $3,650,000 for this initiative, funding up to 10 demonstration sites at approximately $365,000 per site per year. The performance period is expected to last four years, from August 1, 2025, to July 31, 2029. The initiative does not require cost-sharing or matching funds. Eligible applicants include public and private institutions of higher education, non-profits (with or without 501(c)(3) status), state and local governments, independent school districts, Native American tribal organizations, and faith-based organizations. Individuals are not eligible to apply.

Applications must be submitted through Grants.gov by March 11, 2025, at 11:59 PM ET, with award notifications expected by July 2, 2025. HRSA encourages applicants to secure their SAM.gov and Grants.gov registrations in advance, as these processes can take several weeks. An informational webinar will be provided, and a technical assistance (TA) webpage will be available for applicants.

Applicants must provide a project narrative, including an assessment of the population's healthcare needs, the proposed approach, and how the intervention will be implemented and evaluated. The narrative should outline a high-level work plan, describe challenges and solutions, detail performance reporting and evaluation strategies, and include sustainability plans beyond the funding period. Additionally, applicants must submit a budget and budget narrative, staffing plan, biographical sketches for key personnel, a project organizational chart, and any agreements with external entities.

The selection process will be merit-based, evaluating applications on need (10 points), response (40 points), performance reporting and evaluation (10 points), impact (10 points), resources and capabilities (25 points), and support requested (5 points). HRSA will consider geographic diversity and program alignment when making final funding decisions.

For inquiries, applicants can contact Tonya Bowers, DNP, RN at SPNS@hrsa.gov for program and eligibility questions or Beverly Smith, MHS, RRT at bsmith@hrsa.gov (301-443-7065) for financial and budget-related questions.