The Strategic Prevention Framework-Partnership for Success for States (SPF-PFS-States) grant program by SAMHSA focuses on strengthening state and local prevention capacities to reduce substance use and its associated problems. Applicants are expected to develop community-based services to enhance protective factors, reduce risks, and build resilience in underserved communities. The grant supports implementing evidence-based, evidence-informed, and community-defined strategies to address local substance use concerns, including underage drinking, cannabis, opioids, tobacco, and other emerging substances.

This funding opportunity is open to U.S. states, territories, and jurisdictions, excluding current SPF-PFS recipients funded from FY 2021 to FY 2024. Eligible applicants should demonstrate the ability to address substance use prevention among underserved populations disproportionately affected by substance use disorders (SUD), including racial and ethnic minorities, LGBTQ+ communities, rural populations, and those impacted by systemic inequities. Priority will be given to proposals focusing on communities where at least 50% of the target population is underserved and significantly affected by SUD. Successful applicants may receive up to $2,000,000 annually for five years, contingent on performance and funding availability.

The program emphasizes a data-driven approach based on SAMHSA’s Strategic Prevention Framework (SPF), which includes assessment, capacity building, planning, implementation, and evaluation. Awardees must address up to three state-identified substance use prevention priorities and develop detailed statewide health assessments and improvement plans. Grantees are required to collaborate with community providers, prevention organizations, and anchor institutions such as schools and faith-based groups. Two funding models are available: direct technical assistance to communities or grants to subrecipients for local prevention efforts, with a minimum of two subrecipients funded under the latter model.

Application components include a project narrative, budget narrative, and several attachments such as timelines, letters of commitment, and data collection instruments. Applicants must register with SAM.gov, Grants.gov, and eRA Commons and submit their proposals electronically by March 18, 2025, at 11:59 p.m. ET. Detailed reporting requirements include quarterly updates, annual programmatic progress reports, and comprehensive evaluations of implemented strategies. The proposed projects must align with SAMHSA’s principles of equity, recovery, and trauma-informed approaches.

Grants will be awarded no later than September 29, 2025, with projects starting on September 30, 2025. Additional guidance, including templates and resources, is available in the SAMHSA application guide and related online tools.