The NSF Directorate for Computer and Information Science and Engineering (CISE) seeks to award grants intended to support research independence among early-career academicians who specifically lack access to adequate organizational or other resources, and to broaden the set of institutions capable of performing computing research. It is expected that funds obtained through this program will be used to support untenured faculty or research scientists (or equivalent) in their first three years in a primary academic position after the PhD, but not more than six years after completion of their PhD. Applicants for this program may not yet have received any other grants or contracts in the PI role from any department, agency, or institution of the federal government, including from the CAREER program or any other program, post-PhD, regardless of the size of the grant or contract, with certain exceptions as noted below. Serving as co-PI, Senior Personnel, Postdoctoral Fellow, or other Fellow does not count against this eligibility rule. Importantly, the CRII program seeks to provide essential resources to enable early-career PIs to launch their research careers. This funding opportunity also aims to broaden the engagement of investigators in CISE research and therefore is limited to investigators that are either (1) affiliated with an Institution of Higher Education that is not a "very high research activity" R1 institution (according to the Carnegie Classification https://carnegieclassifications.iu.edu/) or (2) non-profit non-academic institutions. Faculty at undergraduate and two-year institutions may use funds to support undergraduate students, and may optionally use the additional RUI designation (which requires inclusion of a RUI Certification and RUI Impact Statement) -- see https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5518 for additional information. In addition, submissions from all institutions may use funds for PI salary, postdoctoral scholars, travel, and/or research equipment.