The National Institute on Minority Health and Health Disparities (NIMHD), with other NIH Institutes and Centers (ICs) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications from National Cancer Institute (NCI)-designated Cancer Centers with existing community outreach and collaborations with American Indian and Alaska Native populations for research on improving cancer outcomes. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Summer 2024 with an expected application due date in Summer 2024. This NOFO will utilize the U01 activity code. Details of the planned NOFO are provided below.