The purpose of this program is to support communities to directly increase the diagnoses, treatment, and prevention of Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), and syphilis. Successful applicants will work toward a reduction of new HIV infections and relevant co-morbidities, specifically syphilis and HCV infections; improve HIV/HCV/syphilis-related health outcomes; and reduce HIV/HCV/syphilis-related health disparities among American Indian and Alaska Native (AI/AN) people. In four separate but related parts, this initiative aims to implement effective and innovative strategies, interventions, approaches, and services to reduce new HIV/HCV/syphilis infections among AI/AN communities in the U.S. This initiatives overarching goals are to: (1) Reduce new HIV, HCV, and syphilis infections to less than 3,000 per year by 2030; and (2) achieve a 90 percent reduction in new HCV infections and a 65 percent reduction in mortality, compared to a 2015 baseline.